Antidiarrheal agent overdose
Definition
Antidiarrheal agents are drugs used to treat loose, watery, and frequent stools. This article discusses overdose of antidiarrheal drugs containing diphenoxylate or atropine.
Alternative Names
Lomotil overdose
Poisonous Ingredient
- Diphenoxylate
- Atropine
Where Found
- Diphenatol
- Lofene
- Logen
- Lomanate
- Lomotil
- Lonox
- Lo-Trol
- Nor-Mil
Symptoms
- Coma
- Constipation
- Delirium
- Drowsiness
- Dry mouth and skin
- Flushing
- Loss of desire to do anything
- Pinpoint pupils
- Rapid heartbeat
- Rapid side to side eye movement
- Slow breathing
Note: Symptoms may take up to 12 hours to appear.
Home Care
Seek immediate medical help. Do NOT make a person throw up unless told to do so by Poison Control or a health care professional.
Before Calling Emergency
Determine the following information:
- Patient's age, weight, and condition
- Name of the product (ingredients and strengths if known)
- Time it was swallowed
- Amount swallowed
- Name of the medicationprescribed for the patient
Poison Control
The National Poison Control Center (1-800-222-1222) can be called from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.
This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.
Take the prescription bottle with you to the hospital, if possible.
See: Poison control center - emergency number
What to Expect at the Emergency Room
The health care provider will measure and monitor the patient's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated as appropriate. The patient may receive:
- Activated charcoal
- Laxative
- Narcotic-counteracting drug (antagonist), approximately every 30 minutes
- Tube through the nose into the stomach to empty the stomach (gastric lavage)
Outlook (Prognosis)
Most patients will normally recover with treatment and 24 hours of monitoring. However, deaths may occur in young children.
Reviewed By: Eric Perez, MD, Department of Emergency Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY. Review provided by VeriMed Healthcare Network.
