• enlarged hands
• enlarged feet
• widened fingers or toes due to skin overgrowth with swelling, redness, and pain
• enlarged jaw (prognathism) and tongue
• enlarged facial bones
• thickening of the skin, skin tags
• enlarged sebaceous glands
• hoarseness
• headache
• easy fatigue
• excessive sweating
• decreased muscle strength (weakness)
• limited joint mobility
• joint pain (hip pain, knee pain, ankle pain, foot pain, pain over the small joints of the foot, shoulder pain, elbow pain, wrist pain, hand pain, pain over the small joints of the hand, or pain in any other joint)
• carpal tunnel syndrome
• widely spaced teeth
• swelling of the bony areas around a joint

Additional symptoms that may be associated with this disease:

• weight gain (unintentional)
• hair, excessive on females

• The level of growth hormone is high.
• The level of IGF-1 (insulin-like growth factor 1) is high.
• A spine X-ray shows abnormal bone growth.
• A cranial MRI or cranial CT scan may show a pituitary tumor.

This disease may also alter the results of the following tests:

• fasting plasma glucose (high)
• glucose tolerance test (too high at 2 hours)
• creatinine
• creatinine - urine
• 17-ketosteroids
• 17-hydroxycorticosteroids