A class of acid-suppressing medications called proton pump inhibitors (for example, omeprazole, lansoprazole) is now first line treatment of Zollinger-Ellison syndrome. These drugs dramatically reduce acid production by the stomach and promote healing of ulcers in the stomach and small bowel. They also provide relief of abdominal pain and diarrhea.

Surgical removal of a single gastrinoma may be attempted if there is no evidence that it has spread to other organs (such as lymph nodes or the liver). Surgery on the stomach (gastrectomy) to control acid production is rarely necessary today.

Early diagnosis and surgical resection is associated with a cure rate of only 20% to 25%. However, gastrinomas grow slowly, and patients may live for many years after the tumor is discovered. Acid-suppressing medications are very effective at controlling the symptoms of acid overproduction.

• Spread of the tumor to other organs (most often liver and lymph nodes)
• Failure to locate the tumor during surgery
• Intestinal bleeding or perforation from ulcers in the stomach or duodenum
• Severe diarrhea and weight loss

Call your provider if severe, persistent abdominal pain occurs, especially if it occurs with diarrhea.