Replacement therapy with corticosteroids will control the symptoms of this disease. However, these drugs must usually be continued for life. Usually a combination of glucocorticoids (cortisone or hydrocortisone) and mineralocorticoids (fludrocortisone) are given.

Medication may need to be increased during times of stress, infection, or injury.

Adrenal crisis is an extreme manifestation of symptoms of adrenal insufficiency precipiated by physical stress. Intravenous or intramuscular injection of hydrocortisone must be given immediately to sustain life. Supportive treatment for low blood pressure is usually necessary as well.

Some people with Addison's disease are taught to give themselves an emergency injection of hydrocortisone during stressful situations. It is important for the individual with Addison's disease to always carry a medical identification card that states the type of medication and the proper dose needed in case of an emergency.

Never skip doses of medication for this condition, as life-threatening reactions may occur. If unable to retain medication due to vomiting, notify your health care provider, go to the emergency room, or call the local emergency number (such as 911) immediately.

Also report sudden weight gain or fluid retention to the health care provider.

• Diabetes
• Thyrotoxicosis
• Hashimoto's thyroiditis
• Hypoparathyroidism
• Pernicious anemia
• Ovarian hypofunction or testicular failure

Call your health care provider if Addison's disease has been diagnosed and stress such as infection, injury, trauma of any kind, or dehydrating illnesses occur. Medication adjustment may be indicated.

Call your health care provider if weight increases progressively, the ankles begin to swell or other new symptoms develop.

If symptoms of adrenal crisis (low blood pressure, diminished consciousness, difficulty breathing, abdominal pain) occur, give an emergency injection of prescribed medication as instructed or if this is not available, go to the emergency room or call the local emergency number (such as 911).