There is no treatment for the infertility associated with this syndrome. Testosterone therapy will improve the development of secondary sexual characteristics. Testosterone treatment usually starts at the beginning of puberty. Once this treatment begins, it needs to be continued for life. The testicular changes that lead to infertility are not preventable.

Enlarged breast tissue (Gynecomastia) can be treated with plastic surgery if it is disfiguring.

Counseling may benefit people with emotional difficulties due to sexual dysfunction and to reinforce male identity.

The Klinefelter Syndrome Association can be reached at PO Box 119, Roseville, CA, 95678-0119.

The syndrome is associated with an increased risk of breast cancer, extragonadal germ cell tumor (a rare tumor), pulmonary disease, varicose veins, and osteoporosis. There is also an increased risk for autoimmune disorder such as lupus, rheumatoid arthritis, and Sjogren's syndrome.

Learning disabilities, despite normal or high IQ are common. The risk of dyslexia and attention deficient hyperactivity disorder may also be higher. Psychological problems like depression are associated with sex-linked disorders.

Taurodontism, an enlargement of the pulp of the teeth with surface thinning, is very common in Klinefelter syndrome. It can be diagnosed by dental x-rays.