There is no cure for this disease. At first, treatment focuses on controlling symptoms, minimizing complications, and slowing the progression of the disease. Because of the loss of water and salt, the patient will need a liberal intake of both to avoid dehydration.

As the disease progresses, kidney failure develops and appropriate changes will be made:

• If high blood pressure develops, anti-hypertensive medications may be needed.
• Anemia may require erythopoeitin treatment to build red blood cells.
• Diet will be modified to limit phosphorous- and potassium-containing foods.

Once end-stage kidney disease approaches, dialysis may be started. If a suitable donor becomes available, a kidney transplant may be performed.

• Hyponatremia, a disorder of fluid and electrolyte imbalance
• End-stage kidney disease
• Pericarditis, cardiac tamponade
• Platelet dysfunction
• Gastrointestinal bleeding, ulcers
• Hemorrhage
• Anemia
• Peripheral neuropathy
• Weakening of the bones, fractures, joint disorders
• Permanent skin pigmentation changes
• Itching
• Changes in glucose metabolism
• Changes in electrolyte levels, electrolyte abnormalities including hyperkalemia
• Miscarriage, menstrual irregularities, infertility
• Congestive heart failure
• Hypertension