There is no cure for MSA, and there is no known means to slow progression. Treatment is aimed at controlling symptoms such as postural hypotension and parkinsonian movements.

Anticholinergic medications may be used to reduce early or mild tremors. Levodopa may improve movement and balance.

Carbidopa may reduce the side effects of Levodopa and make it work better. However, the response to medications may be disappointing. Many affected individuals respond poorly to treatment with anticholinergics or Levodopa.

Medications that may be used to treat low blood pressure include the following:

• Sympathomimetics
• Vasoconstrictors
• Beta-blockers
• MAO inhibitors
• Vasopressin
• 9-fluohydrocortisone

A pacemaker programmed to stimulate the heart to beat at a rapid rate (faster than 100 beats per minute) may increase blood pressure for some people.

The probable outcome is poor. There is a progressive loss of mental and physical functions until general debilitation develops. Early death is likely.

Rate of progression differs in every case and speed of decline may vary widely in individual patients.

• Progressive loss of ability to walk or care for self
• Difficulty performing daily activities
• Injuries from falls/fainting
• Side effects of medications

Call your health care provider if you develop symptoms of this disorder.

Call your health care provider if you have been diagnosed with MSA and your symptoms recur, worsen, or progress. Also call if new symptoms appear, including possible side effects of medications:

• Involuntary movements
• Nausea/vomiting
• Dizziness
• Changes in alertness/behavior/mood
• Severe confusion or disorientation
• Delusional behavior
• Hallucinations
• Loss of mental functioning

See also the specific medication for possible side effects.

Consult with your health care provider if you have a family member with this disorder and his or her condition deteriorates to the point that you are unable to care for the person at home.