• Vaginal bleeding in pregnancy during the first trimester
• Nausea and vomiting, severe enough to require hospitalization in 10% of cases
• An abnormal growth in the size of the uterus, for the stage of the pregnancy
  • Excessive growth in approximately 1/2 of cases
  • Smaller than expected growth in approximately 1/3 of cases
• Symptoms of hyperthyroidism:
  • Rapid heart rate
  • Restlessness, nervousness
  • Heat intolerance
  • Unexplained weight loss
  • Loose stools
  • Trembling hands
  • Skin warmer and more moist than usual
• Symptoms similiar to preeclampsia that occur in the 1st trimester or early in the 2nd trimester. (This is nearly diagnostic of a hydatiform mole, because preeclampsia is extremely rare this early in normal pregnancies.)
  • High blood pressure
  • Swelling in feet, ankles, legs
  • Proteinuria

Note: All symptoms occur in conjunction with a potential, suspected, or confirmed pregnancy.

A pelvic examination may show signs similar to a normal pregnancy, but the uterine size may be abnormal and fetal heart tones are absent. Additionally, some bleeding may be noted.

Tests typically include:

• Measurement of serum HCG to confirm pregnancy. Repeated HCG measurements can be used to monitor the rate and consistency of decline if a hydatidiform mole is suspected.
• An ultrasound of the pelvis.
• A chest X-ray and abdominal CT or MRI will be recommended for some patients.

This disease may also alter the results of the following tests:

• Transvaginal ultrasound
• HCG (quantitative)