Treatment for penile cancer varies depending on the location and degree of involvement of the tumor.

CHEMOTHERAPY
Chemotherapy may be used in addition to surgical excision (cutting out and removing) of the penile tumor. Bleomycin is usually the chemotherapy drug of choice for treating penile cancer.

You will usually be hospitalized for the first few doses of chemotherapy to monitor for possible side effects. Most people receive their chemotherapy (after the initial dose) on an outpatient basis at a clinic or physician's office. Possible side effects are numerous and depend on the specific chemotherapy medicine used.

SURGERY:
If the tumor is limited to a small lesion (affected area of tissue damage) near the tip of the penis, a partial penectomy (removal of a portion of the penis) may be performed using general anesthesia. The cancerous portion of the penis is removed. The patient is usually able to urinate normally after this procedure.

A total penectomy with creation of a urethrostomy (new urethral opening created in the groin area) is often necessary when the tumor is more advanced. This procedure is performed using general anesthesia.

LIFESTYLE CHANGES:
It is recommended that you discuss your fears and concerns regarding sexual function and body image prior to surgery. Urination and sexual function can often be maintained, even when a significant portion of the penis is removed. Additionally, the stress associated with diagnosis and treatment of penile cancer can often be helped by joining a support group where members share common experiences and problems. See support group - cancer.

RADIATION THERAPY
A course of radiation therapy is often recommended in conjunction with surgical removal of localized and non-metastatic tumors. A common method of radiation therapy, external beam therapy, is performed usually on an outpatient basis by specially trained radiation therapists. Prior to treatment, a therapist will mark the location that is to be radiated with a semipermanent marking pen. The external beam radiation therapy is delivered to the penis using a device that resembles a normal X-ray machine.

The treatment itself is generally painless, however, there are several side effects associated with radiation therapy. Possible side effects include loss of appetite, fatigue, skin reactions such as redness and irritation, rectal burning or injury, cystitis (inflamed bladder), and hematuria (blood in urine).

External beam radiation therapy is usually performed 5 days a week for 6 to 8 weeks.