- family history of Apert syndrome
-
skeletal (limb) abnormalities
- early closure of sutures between bones of the skull, noted by ridging along sutures
- large or late-closing soft spot on a baby's skull
- unusual facial appearance resulting from severe under-development of the mid-face
- prominent and/or bulging eyes
- fusion or severe webbing of several adjacent fingers and toes (severe syndactyly), often called "mitten hands"
- intellectual development may be retarded to varying degrees
- short stature
- hearing loss
- frequent ear infections
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