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Migraine Headaches

Description

An in-depth report on the causes, diagnosis, treatment, and prevention of migraine.

Lifestyle Changes

Avoiding Food Triggers. Avoiding foods that trigger migraine is important in people who are susceptible to these triggers. Keeping a headache diary that includes tracking diet and headache onset can help identify them.

Healthy Diet. One study indicates that a diet low in fat and high in complex carbohydrates may significantly reduce the frequency, severity, and duration of migraine headaches. Such a diet is healthy in general in any case.

Eating Regularly. Eating regularly is important to prevent low blood sugar. People with migraines who fast periodically for religious reasons might consider taking preventive medications.

Fish Oil. Some studies suggest that omega-3 fatty acids, which are found in fish oil, have anti-inflammatory and nerve protecting actions. These fatty acids can be found in oil fish, such as salmon, mackerel, or sardine. They can also be obtained in supplements of specific omega-3 compounds (DHA-EPA).

Smelling Pleasurable Foods. One interesting study suggested that smelling certain pleasurable foods may reduce migraine pain. (The study used green apples as part of the experiment; patients with headaches who liked the smell of green apples had less pain. The scent had no effect on those who didn't like the fruit.)

Foods That May Trigger Migraines

Foods and Additives

Responsible Chemical

Beers, wines, certain liquors, cheese and cheese-food products, fresh and processed meat (e.g., hotdogs, seafood products, peas, pickles, olives, and sauerkraut).

Tyramine and phenylethylamine. (These chemicals tend to become more potent in foods that are stored improperly.)

Apple juice, coffee, red wine, and tea.

Tannin. Caffeine withdrawal (coffee, tea).

Preservatives in wines, dried fruits, and other products.

Sulfites.

A common seasoning, most notably found in food prepared by Chinese restaurants but also contained in many commercial products.

Monosodium glutamate.

Chocolate.

Amines. Of note: some research suggests that chocolate may not trigger headaches. Instead, a craving for sweets often precedes a headache and so each chocolate may be perceived as a trigger.

Artificial sweeteners.

Aspartame.

Sleep Hygiene

Improving sleep habits is important for everyone, and especially those with headaches.

Aerobic Exercise

Exercise is certainly helpful for relieving stress and an analysis of several studies reported that aerobic exercise might help prevent migraines. It is important, however, to warm up gradually before beginning a session, since sudden, vigorous exercise might actually precipitate or aggravate a migraine attack.

Avoiding Oral Contraceptives

Hormonal agents, such as oral contraceptives (OCs) or hormone replacement therapy, have a mixed effect on women with migraines. Oral contraceptives (OCs) have been associated with worse headaches in 18% to 50% of women and have also been linked to a higher risk for stroke in women with classic migraines (with auras). Young women should avoid or stop oral contraception if they have classic migraines, migraines that worsen or change character after OCs, if they have close relatives with stroke or heart disease, or if they smoke.

Some evidence suggests, however, that OCs may help prevent true menstrual migraines (which do not have auras). In such cases, their benefits may outweigh the low risk of a serious adverse event. Keeping a migraine record for at least three menstrual cycles can help to confirm whether a woman actually has a true menstrual migraine.

Behavioral Treatments

Behavioral techniques that reduce stress and empower the patient may help some people with migraines. Studies report between 35% and 50% reduction in migraine and tension-type headaches with these approaches. They generally include the following:

  • Biofeedback therapy.
  • Cognitive-behavioral therapy.
  • Relaxation techniques.

Behavioral methods may help counteract the tendency for muscle contraction and uneven blood flow associated with some headaches. They may be particularly beneficial for children, adolescents, and pregnant and nursing women, and anyone who cannot take most migraine medications.

Biofeedback. Studies have demonstrated some effectiveness from biofeedback for migraine headaches. Biofeedback training teaches the patient to monitor and modify physical responses, such as muscle tension, using special instruments for feedback.

Cognitive Behavioral Therapy. Behavioral therapy may be useful alone but is particularly beneficial for patients who are on preventive drug treatments. It typically employs the headache diary to track activities and headaches. The patient then works with the therapist to change or add behaviors or medications that will reduce the frequency and severity of attacks.

Alternative Treatments

People increasingly use alternative remedies for chronic problems. It should be strongly noted that alternative or natural remedies are not regulated and their quality is not publicly controlled.

Non-Drug Therapies. Alternative non-drug therapies used for headache management include hypnosis, meditation, visualization and guided imagery, acupuncture, acupressure, yoga, and other relaxation exercises. There is no clear evidence that any of these techniques have specific value for migraines.

Some studies report the following:

  • Acupuncture. A number of individuals have tried acupuncture with varying response. In one 2003 study, it had some benefits in the early treatment of a migraine attack, but a triptan was more effective at relieving the headache.
  • Relaxation Techniques. Muscle relaxation techniques may be helpful. One interesting 2001 study reported that relaxation treatments appeared to help adolescents with migraine but not tension headaches.
  • Electrical Stimulation. Small studies have found that therapy with transcutaneous electrical stimulation (TENS) may reduce migraine headache episodes. The procedure involves a very mild electrical sensation across the skin. One course of TENS takes about a half hour. One report suggests that using TENS with acupuncture points, along with self-hypnosis and relaxation techniques, may be an effective management option among patients with migraine headaches, but long-term and well-conducted studies are needed to confirm this.

Riboflavin (Vitamin B2). There is reasonable evidence on the benefits of vitamin B2 for migraine sufferers. In one study, patients who took 400 mg of vitamin B2 (riboflavin) reduced their migraine attacks by half, although the vitamin had no effect on the severity or duration of migraines that did occur. In another study, it helped increase the effectiveness of beta-blockers, drugs used to prevent migraines in some people. Vitamin B2 is generally safe, although some people taking high doses develop diarrhea.

Feverfew. Feverfew is the most studied herbal remedy for headaches and is effective in some cases. It should be noted, however, that, like all effective headache remedies over use can cause a rebound effect. Some experts recommend purchasing feverfew in dried leaf form. It appears to be safe, but side effects can be distressing.

Phytoestrogens. Phytoestrogens are plant products that have estrogen-like properties. They include soy and black cohosh. In one study, a combination of soy compounds, dong quai, and black cohosh was associated with a lower risk for menstrual migraines. Because of the association between oral contraceptives, which contain estrogen, and a higher risk for stroke in people with migraines, no one should take such remedies without consulting a physician.

Glucosamine. Glucosamine is a natural substance being used with some success for patients with osteoarthritis. Anecdotal reports are suggesting that the use of this agent may prevent migraines. As with other natural remedies, products are not regulated by the FDA. It is being well studied for arthritis, however, and to date has few side effects. Many available brands (e.g., CVS, Walgreens, Wal-Mart) are manufactured with appropriate ingredients.

Coenzyme Q10. Coenzyme Q10 is a natural substance that is important for the transport of electrons. One study reported that patients who took it experienced a significant reduction in migraine headaches after three months.

Magnesium Supplements. Some studies have reported a higher rate of magnesium deficiencies in some migraine patients, such as those with menstrual migraines. Whether supplements are helpful, however, is unproven.

Warnings on Alternative and So-Called Natural Remedies

Alternative or natural remedies are not regulated and their quality is not publicly controlled. In addition, any substance that can affect the body's chemistry can, like any drug, produce side effects that may be harmful. Even if studies report positive benefits from herbal remedies, the compounds used in such studies are, in most cases, not what are being marketed to the public.

There have been a number of reported cases of serious and even lethal side effects from herbal products. In addition, some so-called natural remedies were found to contain standard prescription medication. Of specific concern are studies suggesting that up to 30% of herbal patent remedies imported from China having been laced with potent pharmaceuticals such as phenacetin and steroids. Most reported problems occur in herbal remedies imported from Asia, with one study reporting a significant percentage of such remedies containing toxic metals.

The following of are particular importance of migraine patients:

  • Feverfew. It appears to be safe, but side effects can be distressing, particularly canker sores in the mouth (5% to 15% of cases) and stomach distress. This agent should not be taken during pregnancy or in women hoping to become pregnant. People with any blood clotting disorders should not take it.
  • Black cohosh. Black cohosh (also known as Cimicifuga racemosa or squaw root) has been used for decades in Germany and appears to be safe, but because its actions resemble estrogen, well-conducted clinical studies are needed to confirm both long-term safety and effectiveness. One study, for example, reported an association between black cohosh and cell proliferation in the uterus, which theoretically could increase cancer risk. Headaches and gastrointestinal problems are common side effects. At this time experts do not recommend taking it for more than six months.
  • Dong quai. Dong quai does not act like an estrogen, but appears to contain B vitamins, anti-inflammatory factors, muscle relaxants, and possibly progesterone-like substances. Dong quai should not be used with blood-thinning agents, such as warfarin. It may also increase the risk of skin cancers.

The following website is building a database of natural remedy brands that it tests and rates. Not all are yet available (www.consumerlab.com).

The Food and Drug Administration has a program called MEDWATCH for people to report adverse reactions to untested substances, such as herbal remedies and vitamins (800-332-1088).

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